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1

Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction

Wikberg, Jarl E. S., Mutulis, Felikss

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 1.11 MB

english, 2008

2

Discovery of novel melanocortin4 receptor selective MSH analogues

Helgi B Schiöth, Felikss Mutulis, Ruta Muceniece, Peteris Prusis, Jarl E S Wikberg

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 352 KB

english, 1998

3

Loss of Function Mutations of the Human Melanocortin 1 Receptor Are Common and Are Associated with Red Hair

Helgi B. Schiöth, Siôn R. Phillips, Richard Rudzish, Mark A. Birch-Machin, Jarl E.S. Wikberg, Jonathan L. Rees

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 67 KB

english, 1999

4

Selective properties of C- and N-terminals and core residues of the melanocyte-stimulating hormone on binding to the human melanocortin receptor subtypes

Helgi B Schiöth, Felikss Mutulis, Ruta Muceniece, Peteris Prusis, Jarl E.S Wikberg

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 226 KB

english, 1998

5

Semisynthesis of Libiguin A and Its Analogues by Trans-Lactonization of Phragmalin

Grigorjeva, Liene, Liepinsh, Edvards, Razafimahefa, Solofoniaina, Yahorau, Aleh, Yahorava, Sviatlana, Rasoanaivo, Philippe, Jirgensons, Aigars, Wikberg, Jarl E. S.

Journal:

Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 428 KB

english, 2014

6

CryoProtect: A Web Server for Classifying Antifreeze Proteins from Nonantifreeze Proteins

Pratiwi, Reny, Malik, Aijaz Ahmad, Schaduangrat, Nalini, Prachayasittikul, Virapong, Wikberg, Jarl E. S., Nantasenamat, Chanin, Shoombuatong, Watshara

Journal:

Journal of Chemistry

Year:

2017

Language:

english

File:

PDF, 3.34 MB

english, 2017

7

Multivariate analysis of G protein-coupled receptors

Ingrid Gunnarsson, Per Andersson, Jarl Wikberg, Torbjörn Lundstedt

Journal:

Journal of Chemometrics

Year:

2003

Language:

english

File:

PDF, 298 KB

english, 2003

8

ChemInform Abstract: N-Alkylaminoacids and Their Derivatives Interact with Melanocortin Receptors

Felikss Mutulis, Ilze Mutule, Jarl E. S. Wikberg

Journal:

Year:

2002

File:

PDF, 26 KB

2002

9

A non-peptide radioiodinated high affinity melanocortin-4 receptor ligand

Felikss Mutulis, Sviatlana Yahorava, Ilze Mutule, Aleh Yahorau, Sergei Kopanchuk, Santa Veiksina, Ago Rinken, Jarl E. S. Wikberg

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2003

Language:

english

File:

PDF, 146 KB

english, 2003

10

QSAR of multiple mutated antibodies

Ilona Mandrika, Peteris Prusis, Sviatlana Yahorava, Kaspars Tars, Jarl E.S. Wikberg

Journal:

Journal of Molecular Recognition

Year:

2007

Language:

english

File:

PDF, 193 KB

english, 2007

11

Design and synthesis of a library of tertiary amides: Evaluation as mimetics of the melanocortins’ active core

Felikss Mutulis, Jana Kreicberga, Sviatlana Yahorava, Ilze Mutule, Larisa Borisova-Jan, Aleh Yahorau, Ruta Muceniece, Sandra Azena, Santa Veiksina, Ramona Petrovska, Jarl E.S. Wikberg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 708 KB

english, 2007

12

Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases

Peteris Prusis, Maris Lapins, Sviatlana Yahorava, Ramona Petrovska, Pornwaratt Niyomrattanakit, Gerd Katzenmeier, Jarl E.S. Wikberg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 463 KB

english, 2008

13

Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates

Aleksejs Kontijevskis, Ramona Petrovska, Sviatlana Yahorava, Jan Komorowski, Jarl E.S. Wikberg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 518 KB

english, 2009

14

Design of new small cyclic melanocortin receptor-binding peptides using molecular modelling: Role of the His residue in the melanocortin peptide core

Peteris Prusis, Ruta Muceniece, Ilze Mutule, Felikss Mutulis, Jarl E.S. Wikberg

Journal:

European Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

15

N-Alkylaminoacids and Their derivatives interact with melanocortin receptors

Felikss Mutulis, Ilze Mutule, Jarl E.S. Wikberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

16

Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors

Felikss Mutulis, Ilze Mutule, Maris Lapins, Jarl E.S. Wikberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 139 KB

english, 2002

17

The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain

Anna M. S. Kindlundh, Jonas Lindblom, Lena Bergström, Jarl E. S. Wikberg, Fred Nyberg

Journal:

European Journal of Neuroscience

Year:

2001

Language:

english

File:

PDF, 343 KB

english, 2001

18

Brunn: An open source laboratory information system for microplates with a graphical plate layout design process

Jonathan Alvarsson, Claes Andersson, Ola Spjuth, Rolf Larsson, Jarl ES Wikberg

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 2.61 MB

english, 2011

19

Towards interoperable and reproducible QSAR analyses: Exchange of datasets

Ola Spjuth, Egon L Willighagen, Rajarshi Guha, Martin Eklund, Jarl ES Wikberg

Journal:

Journal of Cheminformatics

Year:

2010

Language:

english

File:

PDF, 2.45 MB

english, 2010

20

Rough set-based proteochemometrics modeling of G-protein-coupled receptor-ligand interactions

Helena Strömbergsson, Peteris Prusis, Herman Midelfart, Maris Lapinsh, Jarl E.S. Wikberg, Jan Komorowski

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 480 KB

english, 2006

21

Generalized modeling of enzyme–ligand interactions using proteochemometrics and local protein substructures

Helena Strömbergsson, Andriy Kryshtafovych, Peteris Prusis, Krzysztof Fidelis, Jarl E. S. Wikberg, Jan Komorowski, Torgeir R. Hvidsten

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 527 KB

english, 2006

22

Proteochemometric modeling reveals the interaction site for Trp9 modified α-MSH peptides in melanocortin receptors

Maris Lapinsh, Peteris Prusis, Ramona Petrovska, Staffan Uhlén, Ilze Mutule, Santa Veiksina, Jarl E. S. Wikberg

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 346 KB

english, 2007

23

Computational proteomics analysis of HIV-1 protease interactome

Aleksejs Kontijevskis, Jarl E. S. Wikberg, Jan Komorowski

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 437 KB

english, 2007

24

Proteochemometric analysis of small cyclic peptides' interaction with wild-type and chimeric melanocortin receptors

Aleksejs Kontijevskis, Ramona Petrovska, Ilze Mutule, Staffan Uhlen, Jan Komorowski, Peteris Prusis, Jarl E. S. Wikberg

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 999 KB

english, 2007

25

Improving the affinity of antigens for mutated antibodies by use of statistical molecular design

Ilona Mandrika, Peteris Prusis, Jakob Bergström, Sviatlana Yahorava, Jarl E. S. Wikberg

Journal:

Journal of Peptide Science

Year:

2008

Language:

english

File:

PDF, 1.21 MB

english, 2008

26

Identification of the binding pocket for the TRH peptide in the melanocortin 1 receptor

Peteris Prusis, Ruta Muceniece, Torbjörn Lundstedt, Jarl E. S. Wikberg

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2000

Language:

english

File:

PDF, 339 KB

english, 2000

27

MC3receptors are involved in the protective effect of melanocortins in myocardial ischemia/reperfusion-induced arrhythmias

Salvatore Guarini, Helgi B. Schiöth, Chiara Mioni, Maria Cainazzo, Giuseppe Ferrazza, Daniela Giuliani, Jarl E. Wikberg, Alfio Bertolini, Carla Bazzani

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2002

Language:

english

File:

PDF, 68 KB

english, 2002

28

Localization of ACTH receptor mRNA by in situ hybridization in mouse adrenal gland

Yun Xia, Jarl E. S. Wikberg

Journal:

Cell and Tissue Research

Year:

1996

Language:

english

File:

PDF, 692 KB

english, 1996

29

Modeling of the three-dimensional structure of the human melanocortin 1 receptor, using an automated method and docking of a rigid cyclic melanocyte-stimulating hormone core peptide

Peteris Prusis, Helgi B. Schiöth, Ruta Muceniece, Pawel Herzyk, Mohammad Afshar, Roderick E. Hubbard, Jarl E.S. Wikberg

Journal:

Journal of Molecular Graphics and Modelling

Year:

1997

Language:

english

File:

PDF, 728 KB

english, 1997

30

α2-Adrenoceptors Mediate Inhibition of Cyclic AMP Production in the Spinal Cord After Stimulation of Cyclic AMP with Forskolin but Not After Stimulation with Capsaicin or Vasoactive Intestinal Peptide

Staffan Uhlén, Jarl E. S. Wikberg

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 704 KB

english, 1989

31

Further Characterization of the Guinea Pig Cerebral Cortex Idazoxan Receptor: Solubilization, Distinction from the Imidazole Site, and Demonstration of Cirazoline as an Idazoxan Receptor-Selective Drug

Jarl E. S. Wikberg, Staffan Uhlén

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 1.25 MB

english, 1990

32

Characterization of Guanoxabenz Reducing Activity in Rat Brain

Maija Dambrova, Staffan Uhlén, Jarl E. S. Wikberg

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1998

Language:

english

File:

PDF, 520 KB

english, 1998

33

New Melanocortin 1 Receptor Binding Motif Based on the C-Terminal Sequence of α-Melanocyte-Stimulating Hormone

Helgi B. Schiöth, Ruta Muceniece, Ilga Mutule, Jarl E. S. Wikberg

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

34

Functional Evaluation of THIQ, a Melanocortin 4 Receptor Agonist, in Models of Food Intake and Inflammation

Ruta Muceniece, Liga Zvejniece, Reinis Vilskersts, Edgars Liepinsh, Larisa Baumane, Ivars Kalvinsh, Jarl E. Wikberg, Maija Dambrova

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

35

Pharmacological classification of adrenergic α receptors in the guinea pig

WIKBERG, JARL E. S.

Journal:

Year:

1978

File:

PDF, 305 KB

1978

36

Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist

Gudrun V Skuladottir, Logi Jonsson, Jon O Skarphedinsson, Felikss Mutulis, Ruta Muceniece, Amanda Raine, Ilze Mutule, Johannes Helgason, Peteris Prusis, Jarl E S Wikberg, Helgi B Schiöth

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 351 KB

english, 1999

37

Cardioprotective effects of N-hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats

Maris Veveris, Maija Dambrova, Helena Cirule, Dainuvite Meirena, Ivars Kalvinsh, Jarl E S Wikberg

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 397 KB

english, 1999

38

Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig

Anne Lecklin, Ingrid Lundell, Leena Paananen, Jarl E S Wikberg, Pekka T Männistö, Dan Larhammar

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 222 KB

english, 2002

39

Identification of the binding pocket for the TRH peptide in the melanocortin 1 receptor

Peteris Prusis, Ruta Muceniece, Torbjörn Lundstedt, Jarl E. S. Wikberg

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2000

Language:

english

File:

PDF, 40 KB

english, 2000

40

Towards Proteome–Wide Interaction Models Using the Proteochemometrics Approach

Helena Strömbergsson, Maris Lapins, Gerard J. Kleywegt, Jarl E. S. Wikberg

Journal:

Molecular Informatics

Year:

2010

Language:

english

File:

PDF, 482 KB

english, 2010

41

Classification of G-protein coupled receptors by alignment-independent extraction of principal chemical properties of primary amino acid sequences

Maris Lapinsh, Alexandrs Gutcaits, Peteris Prusis, Claes Post, Torbjörn Lundstedt, Jarl E.S. Wikberg

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 3.49 MB

english, 2002

42

Characterization of Adrenoceptor Types and Subtypes in American Bullfrogs Acclimated to Warm or Cold Temperature

Ceil A. Herman, Georgia Luczy, Jarl E.S. Wikberg, Staffan Uhlén

Journal:

General and Comparative Endocrinology

Year:

1996

Language:

english

File:

PDF, 171 KB

english, 1996

43

Evidence for the existence of two forms of α2A-adrenoceptors in the rat

Staffan Uhlén, Yun Xial, Vijay Chhajlanil, Eric J. Lien, Jarl E. S. Wikberg

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

44

Functional expression of rat α2B-adrenoceptor in Escherichia coli

Yun Xia, Vijay Chhajlani, Jarl E.S. Wikberg

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1993

Language:

english

File:

PDF, 402 KB

english, 1993

45

Characterisation of melanocortin receptor subtypes by radioligand binding analysis

Helgi B. Schiöth, Ruta Muceniece, Jarl E.S. Wikberg, Vijay Chhajlani

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1995

Language:

english

File:

PDF, 601 KB

english, 1995

46

Polyclonal antibodies against human melanocortin MC1 receptor: preliminary immunohistochemical localisation of melanocortin MC1 receptor to malignant melanoma cells

Yun Xia, Valdemar Skoog, Ruta Muceniece, Vijay Chhajlani, Jarl E.S. Wikberg

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

47

β- and γ-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain

Ruta Muceniece, Liga Zvejniece, Olga Kirjanova, Edgars Liepinsh, Liga Krigere, Larisa Baumane, Ivars Kalvinsh, Jarl E.S. Wikberg, Maija Dambrova

Journal:

Year:

2004

Language:

english

File:

PDF, 398 KB

english, 2004

48

Co-operative regulation of ligand binding to melanocortin receptor subtypes: Evidence for interacting binding sites

Sergei Kopanchuk, Santa Veiksina, Ramona Petrovska, Ilze Mutule, Michael Szardenings, Ago Rinken, Jarl E.S. Wikberg

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 252 KB

english, 2005

49

A new protolimonoid from Capuronianthus mahafalensis

Torgils Fossen, Philippe Rasoanaivo, Christian Sambany Manjovelo, Fanja Hanitriniala Raharinjato, Sviatlana Yahorava, Aleh Yahorau, Jarl Erik Sylvester Wikberg

Journal:

Year:

2012

Language:

english

File:

PDF, 581 KB

english, 2012

50

beta-MSH inhibits brain inflammation via MC3/4 receptors and impaired NF-κB signaling

Ruta Muceniece, Liga Zvejniece, Olga Kirjanova, Edgars Liepinsh, Liga Krigere, Reinis Vilskersts, Larisa Baumane, Valentina Gordjusina, Ivars Kalvinsh, Jarl E.S. Wikberg, Maija Dambrova

Journal:

Journal of Neuroimmunology

Year:

2005

Language:

english

File:

PDF, 317 KB

english, 2005

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